*Sponsored Post*

Adipose Tissue Banking

Adipose Tissue and Stem Cell Banking by Netcells gives individuals the opportunity to store their Adipose Tissue (fat) and/or stem cell-containing Stromal Vascular Fraction (SVF) for later autologous use (for oneself).

Adult fat tissue is easily harvested following a standard liposuction procedure, processed and cryopreserved. The stored tissue is then quickly retrievable should it be required for a clinical application.

4 1

Adipose tissue and the Stromal Vascular Fraction (SVF)

Adipose Tissue is commonly discarded as medical waste but can be processed and stored in its natural form, up to a maximum of 250ml. Adipose tissue is easily and safely obtained via a liposuction procedure conducted by a professional. It is then sent to the Next Biosciences’ laboratory where it is received, processed, and cryopreserved following strict protocols.

Adipose tissue provides a rich source of stem cells which are contained in the Stromal Vascular Fraction (SVF). The SVF describes the heterogeneous (containing different cell types) cell portion that is extracted from adipose tissue. It contains so-called adipose-derived stem cells (ADSCs) as well other cells and a range of growth factors and signalling molecules which may have regenerative properties. When used autologously, SVF poses no risk of immune rejection. Importantly, SVF refers to a cell product that is not culture expanded.

A more homogenous cell product of adipose stem cells (ASCs) may be obtained by culture expansion; however, this is a different product entirely and is not being offered by Netcells at the current point in time. Should you wish to store the SVF, any free lipid is first removed from the adipose tissue and the remaining tissue is then processed to isolate and cryopreserve the SVF cell fraction.

Clinical applications

Adipose tissue is routinely used for the well-established, simple and safe technique of fat grafting, a surgical procedure where fat is moved from one site in the body to another. This procedure, also known as lipotransfer, has multiple aesthetic uses including facial and body contouring, augmentation of soft-tissue defects and the treatment of contour deformities following breast reconstruction.

Furthermore, the addition of the autologous SVF fraction is being investigated as part of a newer technique, cell-assisted lipotransfer (CAL), which has been shown to improve the long-term viability of the graft. Cell-assisted lipotransfer utilises fat grafts that are enriched with either the SVF or ADSCs. CAL has been tested in small cohorts of patients in several human studies; results suggest that this technique improves the clinical outcome of the transplant and additionally reduces the need for repeated applications in the context of breast augmentation and facial tissue defects.

SVF is currently also being tested in a range of clinical trials for numerous other applications, including a range of orthopaedic, ophthalmologic and cosmetic purposes, as well as for the treatment of immune disorders, premature ovarian failure and neuronal diseases such as multiple sclerosis.

SVF may, therefore, in the future, provide a treatment option where conventional methods have failed. A major advantage of SVF for therapeutic use is that it can be obtained and used autologously (for oneself). A patient in need of the regenerative possibilities that SVF has to offer can choose to harvest this cell source from their own fat tissue, allow for it to be processed and then cryopreserved for potential future application.

Written by Dr Carola Niesler, Next Biosciences Chief Scientific Officer.

About Netcells

Netcells, a company of Next Biosciences, is a private stem cell bank, giving individuals the opportunity to collect, process and bank their stem cells for future potential medical and aesthetic use.

The Next Biosciences laboratory is situated in Johannesburg, South Africa. Next Biosciences is both a licensed stem cell and tissue bank with the South African Department of Health and is internationally accredited with the American Association of Blood Banks (AABB) for cord blood stem cells. Next Biosciences Medical Director is a Board Member of the South African Tissue Bank Association (SATiBA).

Get more information

To enquire about Netcells Adipose Tissue and Stem Cell Banking product, please contact netcells@nextbio.co.za or call us on 011 697 2900.

Click here for more info on Adipose Tissue Banking.

Click here for more info on Umbilical Cord Stem Cell Banking. (HIGHLY RECOMMENDED: Please do your homework and ensure you understand who is behind the company you choose to entrust to store your child’s stem cells for the next 20 years).

Website: www.nextbio.co.za

Facebook: www.facebook.com/Netcells1

Instagram: www.instagram.com/netcells1

References

[1] Zuk, PA et al, “Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based Therapies,” Tissue Engineering, vol. 7, p. 2, 2001.

[2] Dykstra, J et al “Concise Review: Fat and Furious: Harnessing the Full Potential of Adipose-Derived Stromal Vascular Fraction,” STEM CELLS Translational Medicine, vol. 6, no. 4, p. 1096–1108, 2017.

[3] Bora P and Majumdar A, “Adipose tissue-derived stromal vascular fraction in regenerative medicine: a brief review on biology and translation.,” Stem Cell Research & Therapy, vol. 8, p. 145, 2017.

[4] Bourin, P et al, “Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics (IFATS) and Science and the ISCT,” Cytotherapy, vol. 15, no. 6, pp. 641-648, 2013

[5] Venkat RM and Nolan BL, “The Adipose Stromal Vascular Fraction as a Complex Cellular Source for Tissue Engineering Applications,” Tissue Engineering , p. 00, 2017.

[6] Alabdulkarim Y, et al (2017) Recent advances in bone regeneration: The role of adipose tissue-derived stromal vascular fraction and mesenchymal stem cells. J Limb Lengthening & Reconstruction 3: 4-18

[7] L. Frese , P. Dijkman and S. Hoerstrup, “Adipose Tissue-Derived Stem Cells in Regenerative Medicine,” Transfusion Medicine and Hemotherapy, vol. 43, no. 4, pp. 268-274, 2016.

[8] Yoshimura K, Sato K, Aoi N, et al. Cell-assisted lipotransfer for cosmetic breast augmentation: supportive use of adipose derived stem/stromal cells. Aesthetic Plast Surg. 2008;32:48e55.
[9] Kamakura T, Ito K. Autologous cell-enriched fat grafting for breast augmentation. Aesthetic Plast Surg. 2011;35:1022-1030

[10] Wang L, Luo X, Lu Y, et al. Is the resorption of grafted fat reduced in cell-assisted lipotransfer for breast augmentation? Ann Plast Surg. 2015;75:128e134.

[11] Yoshimura K, Asano Y, Aoi N, et al. Progenitor-enriched adipose tissue transplantation as rescue for breast implant complications. Breast J. 2010;16:169e175.

[12] Jung HK, Kim CH, Song SY. Prospective 1-year follow-up study of breast augmentation by cell-assisted lipotransfer. Aesthetic Surg J Am Soc Aesthetic Plast Surg. 2015;4

[13] Peltoniemi HH, Salmi A, Miettinen S, et al. Stem cell enrichment does not warrant a higher graft survival in lipofilling of the breast: a prospective comparative study. J Plast Reconstr Aesthetic Surg JPRAS. 2013;66:1494e1503

Rochelle Friedman

Aesthetic Appointment | Website

Rochelle is the founder and driving force behind Aesthetic Appointment. With a passion for the aesthetics and pro-ageing industry in South Africa, she has been in the aesthetic publishing industry since 2012, dedicated to creating a valuable platform for insights and knowledge, bridging the gap between patients and doctors - delivering reliable, medical-based information. Rochelle firmly believes in the power of a good skincare regimen, especially when started at home, and is committed to educating consumers about the myriad of treatments, procedures, and products available to them.