*Sponsored post: Tasosol Aesthetics*
Disclaimer: For medical regulatory reasons, we are unable to publish the brand name of the polynucleotide biostimulator mentioned in this article, manufactured by Promoitalia Medical Aesthetics, and distributed exclusively in South Africa by Tasosol Aesthetics. Please consult your doctor for more information. If you are a healthcare provider, contact Tasosol Aesthetics directly: info@tasosol.co.za | +27 12 346 0656 | +27 82 379 2718
Polynucleotide injectables are reshaping how doctors approach skin rejuvenation by focusing on cellular repair rather than volume alone. In this feature, Dr Cecile Baard explains how polynucleotides support collagen, hydration and tissue healing in a way that feels restorative rather than overdone. From fine lines and scars to hair thinning and loss of elasticity, she unpacks where this treatment fits into modern aesthetic medicine.
Polynucleotide injectables are an innovative addition to aesthetic medicine, offering a bio-stimulating approach to skin rejuvenation. The product discussed in this article is manufactured by Promoitalia Medical Aesthetics and distributed in South Africa through Tasosol Aesthetics. These injectables are designed to enhance cellular repair, hydration, and elasticity — helping skin look healthier and more refined while supporting its natural functions.
Treatment Areas
Polynucleotides can be used across several areas of the body:
- Eyes: To improve under-eye bags, fine wrinkles, and overall skin quality.
- Face and neck: To address dullness, sagging, and uneven texture.
- Scars: For the treatment of surgical scars and small depressed scars.
- Hands: To refine texture and reduce the appearance of age spots.
- Abdomen and thighs: To improve the appearance of cellulite and skin laxity.
- Scalp: The bio-stimulating properties can support hair-loss or thinning concerns.
The Science Behind Polynucleotides
A polynucleotide is a long chain of nucleotides — the molecules that make up DNA and RNA. These may be synthetic or naturally occurring; in aesthetic practice, they are most often derived from responsibly sourced salmon DNA, due to its biocompatibility with human skin.
Approximately 70% of salmon DNA is similar to human DNA. This similarity is due to the shared genetic code and the fact that all living organisms — including salmon and humans — use the same basic building blocks of DNA (nucleotides: adenine, guanine, cytosine, and thymine). The structural functions of DNA are highly conserved across species, allowing salmon-derived DNA to integrate safely and effectively with human cellular processes.
When salmon-derived DNA is introduced into human tissue, the body recognises these nucleotides as natural building blocks for repair and renewal. Cells then recycle these nucleotides to mend damaged DNA or synthesise new RNA. The stability of salmon DNA allows it to remain active for longer periods, promoting sustained regenerative effects.
Its low immunogenicity means it rarely causes immune reactions, making it a safe and well-tolerated option in skin treatments.
How the Treatment Works
Polynucleotides with bio-stimulating properties activate fibroblasts — the cells responsible for producing collagen and elastin. With age, production of these key proteins declines, resulting in sagging and wrinkles.
By boosting collagen and elastin production, polynucleotides improve skin elasticity and firmness, giving a subtle lifting effect over time. The high-viscosity gel formulation also enhances hydration, improving moisture retention and reducing fine lines.
Polynucleotides encourage better microcirculation, which delivers oxygen and nutrients to the skin for improved vitality and faster recovery after treatment. Their regenerative influence extends beyond skin rejuvenation, helping to create an optimal environment for natural tissue repair.
Clinically Supported Benefits
Clinical studies consistently show that polynucleotides can significantly improve skin texture, elasticity, and hydration.
- A study published in the Journal of Drugs in Dermatology found that polynucleotide treatment increased collagen and hyaluronic acid production, resulting in smoother, more youthful-looking skin.
- Improvement of atrophic scars — the depressions in the skin caused by acne — has also been reported.
- Research published in The Journal of Dermatological Treatment highlights their potential in hair restoration, showing stimulation of follicles that may lead to thicker, healthier hair growth.
- Polynucleotides have additionally been shown to decrease pigmentation and increase skin brightness after treatment.
- Overall, clinical outcomes suggest enhanced hydration, elasticity, and structural integrity of the skin.
Risks and Considerations
As with all injectable treatments, it is essential that procedures are performed by qualified medical professionals. Polynucleotide therapy is generally safe and minimally invasive, but individual responses vary.
Mild side effects:
- Temporary redness or swelling, typically resolving within 24–72 hours.
- Minor bruising at the injection site.
Moderate to severe complications:
- Rare allergic reactions, with symptoms ranging from rashes and swelling to anaphylaxis.
- Localised infection due to poor technique or sterilisation.
- Over-injection or incorrect placement can cause palpable or visible bumps.
Proper technique, hygiene, and patient selection minimise these risks.
Suitable and Unsuitable Candidates
Because of their natural composition and versatility, polynucleotides can be used on most patients. The locally available formulation via Tasosol Aesthetics includes three molecular strengths, allowing doctors to tailor treatments according to depth and indication.
Common uses include:
- Treating fine wrinkles and under-eye concerns.
- Enhancing skin texture and tone on the face and neck.
- Supporting skin before and after surgical procedures such as blepharoplasty or facelift.
- Improving small depressed or surgical scars.
- Preparing skin before laser, filler, or energy-based treatments (radiofrequency, IPL, plasma).
Treatment may not be suitable for:
- Vegans, vegetarians, or patients with fish allergies (as the ingredients are animal-derived).
- Those with active infections, immune deficiency, or those using immunosuppressive or blood-thinning medication.
- Pregnant or breastfeeding women.
- Patients with fluid or fat bags under the eyes.
Every patient should be evaluated individually, and expectations discussed clearly before proceeding.
In Summary
Polynucleotide injectables represent a scientifically supported approach to skin bio-restructuring. By promoting cell repair, hydration, and collagen synthesis, they can help restore radiance and resilience to ageing or damaged skin.
As with any medical procedure, outcomes depend on practitioner expertise, product quality, and patient compliance. Treatment should always be performed in sterile conditions by qualified professionals.
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Disclaimer: For medical regulatory reasons, we are unable to publish the brand name of the polynucleotide biostimulator mentioned in this article, manufactured by Promoitalia Medical Aesthetics, and distributed exclusively in South Africa by Tasosol Aesthetics. Please consult your doctor for more information. If you are a healthcare provider, contact Tasosol Aesthetics directly: info@tasosol.co.za | +27 12 346 0656 | +27 82 379 2718
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